The application programming interface (API) will be available to direct customers and will also be used by partners such as the online marketplace cargo.one.
It contains the available routes, capacities and prices, and automatically executes all relevant checks, reports London's Air Cargo News.
Peter Gerber, chief executive of Lufthansa Cargo, said: 'We want to offer our customers seamless digital solutions. To achieve this, we connect digitally with our partners along the transport chain.
'smartBooking is another major step in our digital transformation process. APIs will continue to gain in importance as an interface to our customers.'
Oliver T Neumann, managing director of cargo.one, adds: 'Our aim is to deliver the best customer experience possible and to drive value and efficiency for the airfreight industry. Accordingly, we are excited to be the first Lufthansa Cargo partner to benefit from the new smartBooking API.'