The carrier will use either Boeing's 787 or Airbus SE A350 aircraft for its inaugural US route from Ho Chi Minh City to San Francisco.
The aircraft will also rely on transporting cargo to offset initial low passenger demand. During the Covid crisis, the airline operated charter flights to transport Vietnamese home from the US.
The carrier is facing a 75 per cent drop in revenue this year compared to 2019 after a loss of US$307 million in the first half of 2021.
The Vietnamese government restricted in-bound international flights to those transporting Vietnamese returning home, business experts, and diplomats.
'We forecast travel demand in 2022 will be just about 25 per cent of 2019. This is the worst period of time in aviation history,' said Vietnam Airlines CEO Le Hong Ha.