Big Twin is being developed by Israel Aerospace Industries and GECAS and is based on the Boeing 777-300ER.
It will carry more cargo and be more efficient than its predecessors and is a months-long process that can cost upwards of US$10 million for larger aircraft.
Currently, the Boeing 747 is the largest mainstream cargo plane, but Boeing will stop producing the aircraft in 2022.
The Big Twin also offers a fuel savings of 21 per cent per tonne compared to the Boeing 747-400F aircraft. It also offers a comparable range and fewer engines to service.
The plane will have a cargo door on the side of the fuselage for loading and unloading cargo pallets.